While tracking a young boy with dangerous powers, Dr. Helen Magnus encounters Will Zimmerman, a psychiatric resident who may have what it takes to become her new protege.
Ashley is confronted by the sinister John Druitt who possesses a powerful force. Meanwhile, Dr Will Zimmerman must decide if he will take a leap of faith and join Magnus in the Sanctuary.
Dr Magnus, Ashley, and Dr Will Zimmerman release three women from a mysterious crypt in Scotland. Unbeknownst to them, bringing them back to the Sanctuary for refuge comes with serious repercussions.
An investigation into a string of bizarre robberies leads Magnus and Will to a crime ring of thieves who seem to be able to slip between the cracks of the law...literally.
After their plane crashes in the Himalayas, Magnus and Will become stranded. Soon the other surviving passengers are viciously attacked and it becomes apparent that surviving the cold is the least of their worries.
When a mating pair of cute, furry and seemingly harmless abnormals are brought in for scientific study, the Sanctuary team begin to exhibit some hidden animal attractions for one another.
While leading a covert meeting in Rome, Magnus encounters an old friend from her past who confides that the cabal has come to exact revenge on her for the events in Fata Morgana.