Mysterious Ways focuses on the search for explanations of, and evidence for, seemingly miraculous phenomena by the protagonist Declan Dunn. Dunn is a professor of anthropology at the Northern University of Oregon and is often compared with Indiana Jones due to his energetic enthusiasm for solving a mystery. His passion for miraculous events has its roots in a self-experienced mischance of him being buried under an avalanche and getting out alive. He considers this to be miraculous and attributes it as the turning point in his life. In several episodes he makes references to this event and the impact it had on his life.